Retour aux articles

CyRISBio: custom, creative, and robust

For many years, CyRISBio has been helping companies transition from manual to automated processes. Today, the company is more than ever positioned as an architect of custom automation solutions for R&D laboratories in the life sciences sector.

To mark a new stage in our development, highlighted by our move to new premises, we spoke with Thibaut Ollivier (General Manager) and Daniel Frayssinhes (Sales Manager). Daniel has been driving this venture for over twenty years, while Thibaut took the helm at the end of 2023. Together, they reflect on the origins of CyRISBio, its values, and its driving forces.

Who is behind CyRISBio, and what drives you to lead this project?

Daniel: This story began long before the name CyRISBio existed. I come from the world of biophysics, and early on, I worked with instruments designed to measure, quantify, and characterize molecules. I have always been fascinated by the idea that technology can make things "tangible" that humans can only perceive through their senses, such as taste or sight. To achieve this, I relied heavily on computing, mechatronics, and, more broadly, automated laboratory systems. 

This led me to serve as General Manager of CyBio France, a specialist in automation solutions for microplate handling, for many years. In 2020, CyRISBio was born from the merger of CyBio and Hi-RIS Lab, an expert in IT, robotics, and custom integration.

Today, CyRISBio is the continuation of that story: a team deeply rooted in the laboratory world, with genuine niche expertise, living the daily realities of bench work, throughput challenges, result quality, and traceability.

Thibaut: I come from a completely different background, but what struck me when I joined CyRISBio in 2023 was the alignment between what is said and the reality. Clients speak of a team that is accessible, one that is clear about what it can do, but also honest about what it cannot. 

We are a team passionate about life sciences. Several of us have backgrounds in biophysics, biology, or biochemistry, upon which we have built strong expertise in automation. 

Ultimately, what motivates us all at CyRISBio is the same thing: helping scientists push their research further with more efficient and reliable tools.

How does your approach to automation change the game for laboratories?

Thibaut: The first difference is that we are not locked into a catalog. We are independent and are not forced to "monetize" an in-house product line at any cost. 

We always start with the lab's actual problem: for example, when a client has a manual process that has become a bottleneck (due to a lack of reliability or productivity), or wants to take an existing platform to the next level (improving a process or integrating new devices). Our expertise then lies in intelligently combining existing components to deliver a turnkey, maintainable, scalable, and economically realistic solution.

Daniel: The second difference is our focus on life sciences. Many automation integrators work across a variety of sectors: semiconductors, heavy chemicals, petrochemicals, and so on. We don’t. We live and breathe biological matrices, clinical samples, and biobanks.

This changes how we listen to a client: we understand what a critical time window between two steps means, the viscosity of a solution, the stability of a reagent, and GLP constraints. We are the catalyst needed for their project’s success. 

How would you describe the qualities of CyRISBio?

Thibaut : It’s a combination of creativity, responsiveness, and excellence.

Creativity: Because for us, automation is not a standard product. Every workflow is different, and every lab has its own unique constraints. We often have to invent a new combination of tools: pipettes, incubators, readers, robots, software, consumables, sample storagesolutions…

Responsiveness: Because we are an agile team with short decision-making chains and a genuine closeness to our clients. Based in the Lyon region, we currently work primarily with French partners. When a client calls us, they speak directly to people who know the field, are capable of diagnosing the problem, and can quickly adjust the solution. And our move to Chaponost, with a larger R&D workshop and a dedicated showroom, will allow us to more easily test and co-design future automated laboratory solutions with our clients.

Excellence: Because what we deliver must be robust and function for years. From the design stage, we seek the right balance: reliable, economically realistic, and scalable solutions, backed by a service team capable of supporting the laboratory for years to come.

Can you share some examples that illustrate your impact?

Daniel: We have supported major pharmaceutical companies (Sanofi), CROs (Eurofins), and agribusiness groups (Bayer CropScience), as well as smaller laboratories that were still performing a large portion of their sensitive tasks (preparations, dilutions, etc.) by hand.

Transitioning to a well-designed and well-supported automated laboratory platform has allowed them to increase throughput and stabilize the quality of their results.

Thibaut: What I find telling is the long-term relationships we maintain with our clients over the years. We create a living ecosystem: extensions, migrations to new software, and the addition of new process lines. That is where you see that our job isn't just to sell a robot, but to evolve the laboratory's working tools over time, as needs evolve.

What advice would you give to lab managers looking to automate a process?

Daniel: One of the biggest challenges is that many lab managers have never led an automation project. They know that "things can't go on like this, manually," but they don't know where to start.

Our advice is simple: don't wait until you have everything mapped out to call us.

There is no point in spending months thinking about it alone. Contact us early on. For us, a successful project starts with the right questions: sample types, volumes, biosafety constraints, software, available lab space, actual objectives, and so on.

That is why we strongly encourage labs to contact us during the initial planning stages. When we are presented with a set of specifications that is already set in stone—and sometimes biased—it is often harder to go back and redesign a truly suitable solution. That can be counterproductive and stifle creativity.

What excites you about the future of CyRISBio?

Thibaut: What drives me is, first and foremost, preserving our DNA: fostering curiosity within the team and staying at the forefront of key technologies (AI, robotics, new software solutions, etc.). But it’s also about preparing for the next steps: increasing our visibility, expanding our engineering team, growing our project portfolio, and strengthening our partnerships with clients and suppliers.

Daniel: What personally excites me is the idea of passing the torch to the team. Seeing what we have built over the past two decades continue to evolve, with a team that shares the same values and clients who trust us, is very important to me. I am convinced that the market needs independent companies and that clients benefit from this diversity.

If you would like to discover how CyRISBio can automate your manual workflows, come see us at Forum Labo Lyon or book an appointment with Daniel or Thibaut for a personalized consultation!

Have an automation project in mind?

Describe your process to us, and we will propose a custom solution.

Contact us

Foire aux Questions

Voit notre FAQ

What is the average lead time from initial contact to the delivery of a final solution?

The average lead time for small-scale automation is around 3 months. For more complex laboratory automation, it varies between 4 and 10 months, with an average of 6 months.

Does CyRISBio partner with specialized manufacturers for its pipetting solutions?

Yes, CyRISBio distributes, among other things, Analytik Jena's CyBio automated pipetting platforms, which are used for laboratory liquid handling.

What does CyRISBio's sample management offering include?

Our sample management offering covers automated low-temperature storage (biobanking), incubators, and storage hotels, as well as associated consumables such as compatible microtubes and racks, notably through our partner LVL-Technologies.

What does CyRISBio's laboratory automation offering consist of?

CyRISBio provides automation solutions for liquid handling and dispensing, as well as the integration of robotic platforms to automate complete laboratory workflows, notably leveraging Analytik Jena's CyBio liquid handling platforms.

Does CyRISBio manufacture its own equipment or distribute partner brands?

CyRISBio designs custom solutions and also distributes equipment from recognized specialized manufacturers in laboratory automation, in order to offer its clients the solution best suited to their process constraints.

Which industry sectors does CyRISBio support?

CyRISBio supports laboratories across several sectors: pharmaceuticals, cosmetics, chemicals, food processing, and biology, with automation solutions tailored to each type of process.

Who is CyRISBio?

CyRISBio is a French company specializing in laboratory automation, founded in 1999. Based in Chaponost, in the Lyon region, it designs and distributes robotic and instrumented solutions for laboratory pipetting and sample management.

We want to automate a manual process but have technical concerns regarding our workflows; can we conduct a POC with you?

Yes. Transitioning from a manual laboratory process to an automated one can indeed raise a number of questions and challenges. We will work on providing automation sub-components to address these issues. These will be handled through micro-developments that will strengthen the final solution.

Is there a cost for being put in touch with your project engineers to evaluate a solution for our automation needs?

No! The initial introductory meeting often takes place via video conference. This allows us to quickly and easily introduce ourselves and assess our mutual interest in moving forward. If both parties decide to work together, the project engineer begins their work, and billing is triggered upon the successful completion of the operation.

Do you need detailed specifications to start an automation project?

The more detailed your laboratory automation requirements are, the less room it leaves for our creativity. Ideally, you should define your needs and outline your processes clearly; the final specifications will be established after a few exchanges with the project engineer in charge.

Can you mix tube formats in an automated sample storage Biobank?

Yes, absolutely. It is possible to mix different types of cassettes with varying heights within the automated sample storage system. This allows you to combine everything from tiny 300 µL tubes to 2 mL tubes.

What is the maximum capacity of your -80°C Biobank?

LiCONiC builds custom Biobanks tailored to your required capacity. There are no capacity limits. Examples of previously manufactured systems include the STC 101k0-ULT.

This automated -80°C sample storage system has a capacity of 3.6 million 1 mL tubes, or 38,400 racks of 96 tubes. By using high-density (HD) racks, the capacity increases by over 40% to reach 5.5 million tubes.

What is the smallest capacity of your -80°C biobank?

The smallest automated -80°C sample storage system, the STT 1.5K ULT, has a capacity of 49,920 1 mL tubes, or 520 96-tube racks. By using smaller 300 µL tubes, for example, the capacity increases to 122,800 tubes.

Where are LVL-Technologies 2D microtubes manufactured? Is the supply chain secure and reliable?

The Safe® range of 2D microtubes is designed, manufactured, and tested in Europe within controlled industrial environments that meet the rigorous demands of scientific and biotechnological applications.
This European production ensures consistent quality, full batch traceability, and strict compliance with international standards.

Control over the production and supply chain allows LVL-Technologies to ensure reliable and long-term product availability, even for large-scale projects or long-term biobanking initiatives.
This approach protects users against supply chain disruptions and ensures the continuity of critical research and sample storage operations.

How can I increase storage space in my -80°C freezers?

Significant space savings can be achieved by replacing internal thread tubes with external thread 2D microtubes.
Thanks to the cap design, where the thread sits on the outer top edge of the tube, this configuration allows for reduced height and therefore increased storage density.
Furthermore, switching from 9×9 or 10×10 cryoboxes to an SBS format saves additional space while paving the way for future biobank automation.
Finally, integrating the Hi-Thèque software helps regularly optimize stock organization while ensuring complete and secure sample traceability, both on-site and remotely.
Our teams are at your disposal to assist you with all initiatives aimed at sustainably optimizing your storage capacity.

Are the 2D microtubes in the Safe range guaranteed RNase/DNase-free?

Yes. The 2D microtubes in the Safe® range are guaranteed RNase-free and DNase-free.
They are manufactured under controlled, sterile conditions and undergo strict quality procedures, ensuring their compatibility with molecular biology and genomics applications, as well as the storage of high-value scientific samples.

How can I effectively manage the storage of my 2D microtubes in -20°C or -80°C freezers or liquid nitrogen tanks?

The Safe® range of 2D microtubes is designed to be stored in standard SBS racks or cryoboxes.
LVL-Technologies also offers customized metal storage boxes, compatible with the main models of refrigerators, freezers, and liquid nitrogen tanks available on the market.
Individual identification via 2D DataMatrix code ensures fast, reliable, and secure sample management, facilitating inventory and storage space optimization.
For advanced management, the use of automated scanning systems and tracking software is highly recommended.

In this regard, the Safe® range from LVL-Technologies includes a new generation of scanners capable of reading all types of 2D microtubes, either individually or in SBS racks and/or 9×9 or 10×10 cryoboxes.

Is it possible to evaluate the chemical inertness of the 2D microtube plastic with respect to biological substances?

Yes. The 2D microtubes from the LVL-Technologies Safe® range are manufactured from medical-grade polypropylene (USP Class VI), selected for its high chemical inertness, very low extractables, and compatibility with demanding biological applications.
These materials are perfectly suited for the long-term storage of sensitive biological samples and limit interactions with DNA, RNA, proteins, or other analytes, even under ultra-low temperature conditions over long periods.
Quality and compliance evaluation tests have been conducted to meet the standards of research laboratories and biobanks. Detailed results are available in the LVL-Technologies Technote, upon request.

Should you choose external or internal threading for ultra-low temperature storage?

For ultra-low temperature storage (-80°C and below), LVL-Technologies recommends using external thread 2D microtubes.

This configuration significantly reduces the contact surface between the sample and the inside of the cap, thereby limiting the risk of cross-contamination, material transfer, or unwanted physical-chemical interactions.
These risks are particularly high with internal thread tubes during agitation or centrifugation, where liquid samples can rise and pool along the internal thread.
A comparative study detailing these phenomena is available in the LVL-Technologies Technote, accessible to all our users upon request, in either paper or electronic format.